Post by sandy2 on Oct 26, 2004 9:24:08 GMT -8
Copied from Gerbil Mailing List:
Hi gerbil community,
I just finished a molecular biology project on gerbil coat colour genes.
During this project, I sequenced the Melanocortin-1 receptor (AKA
Extension) gene and I could identify the mutations that lead to the Dark
Eyed Honey and Schimmel phenotypes.
Here is the abstract of my report:
Different coat colour mutations in
the Mongolian gerbil have been
observed. In this report, I tried to
assign those mutations to individual
genes and to analyze them on a
molecular level by obtaining their
sequence and identifying the cause
of the mutation. This was succesful
for two mutations which haven't
been described previously: Dark
Eyed Honey and Schimmel. Both of
them have the same gene mutated:
Melanocortin-1 receptor (Mc1r).
The obtained sequences revealed
that Mc1r^deh did contain a single
base exchange (G->A) at CDS
position 895 and that Mc1r^sch had
two nucleotides exchanged for six
others (AC->GTGATA) between
CDS positions 442/445, resulting in
a frameshift mutation.
The whole report will be accessable on my homepage
www.toffelholm.se/ or
toffelholm.dyndns.org/
Unfortunately, my server doesn't have internet right now, but this
should be fixed in two weeks or so.
Mathias Gabel
mathias.gabel@home.se
Hi gerbil community,
I just finished a molecular biology project on gerbil coat colour genes.
During this project, I sequenced the Melanocortin-1 receptor (AKA
Extension) gene and I could identify the mutations that lead to the Dark
Eyed Honey and Schimmel phenotypes.
Here is the abstract of my report:
Different coat colour mutations in
the Mongolian gerbil have been
observed. In this report, I tried to
assign those mutations to individual
genes and to analyze them on a
molecular level by obtaining their
sequence and identifying the cause
of the mutation. This was succesful
for two mutations which haven't
been described previously: Dark
Eyed Honey and Schimmel. Both of
them have the same gene mutated:
Melanocortin-1 receptor (Mc1r).
The obtained sequences revealed
that Mc1r^deh did contain a single
base exchange (G->A) at CDS
position 895 and that Mc1r^sch had
two nucleotides exchanged for six
others (AC->GTGATA) between
CDS positions 442/445, resulting in
a frameshift mutation.
The whole report will be accessable on my homepage
www.toffelholm.se/ or
toffelholm.dyndns.org/
Unfortunately, my server doesn't have internet right now, but this
should be fixed in two weeks or so.
Mathias Gabel
mathias.gabel@home.se
;D And I like ee gerbils!